We have read with interest the paper by Li and colleagues about the neurotropism of the severe acute respiratory syndrome coronavirus (SARS-CoV-2), responsible of coronavirus disease (COVID-19), recently discovered in China and now worldwide spread. In particular, the paper focuses on the role of the nervous system involvement in causing the respiratory failure. The authors take into consideration the biological similarities of SARS-CoV-2 with two coronaviruses, which globally impacted the recent history: SARS-CoV, discovered in 2002, and Middle East respiratory syndrome coronavirus (MERS-CoV), discovered in 2012. Even if the role of neuroinvasion in COVID-19 severity still remains undefined, the authors correctly underline its important implications. In particular, the treatment options should contemplate this potential trait of SARS-CoV-2, for example considering the obstacle of blood-brain barrier or limiting the use of corticosteroids. The message conveyed by the authors is extremely important and induces specific reflections about COVID-19 management. The lone possibility of the relationship between respiratory failure and neuroinvasion of SARS-CoV-2 should encourage strict clinical monitoring of the patients and researches aimed to clarify the features of this disease.